What is the developmental pathway by which the hematopoietic stem cell gives rise to a macrophage?

A  the hematopoietic stem cell divides, giving rise to a daughter cell that remains a stem cell and a daughter cell that differentiates directly into a macrophage.

B  the hematopoietic stem cell can give rise to either a lymphoid progenitor or a myeloid progenitor; the myeloid progenitor differentiates directly into a macrophage.

C  the hematopoietic stem cell must first generate a cell of the myeloid lineage (as opposed to the lymphoid lineage), then a granulocyte/macrophage progenitor, then a monocyte, and finally a macrophage.

D  The hematopoietic stem cell gives rise to a variety of cells referred to as granulocytes, any one of which can differentiate further into a macrophage.

E  The hematopoietic stem cell can follow two paths, one called lymphoid and the other called myeloid, either of which can ultimately give rise to macrophages and other cell types such as osteoclasts and T cells.