Mastery EAQ Ch. 2

A  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

B  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin. Probenecid prevents the renal excretion of amoxicillin.

C  Combination therapy is beneficial to the patient. Probenecid prevents the renal excretion of amoxicillin. Probenecid increases the duration of action of amoxicillin.

D  Probenecid reduces allergic reactions to amoxicillin. Probenecid increases the duration of action of amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

A  Prophylactic

B  Empiric

C  Supplemental

D  Maintenance

A  Shortened duration of drug actions

B  Delay in drug absorption

C  Decreased pharmacologic effects of drugs

D  Development of drug toxicity

A  Rash

B  Urticaria

C  Anaphylactic shock

D  Hypotension

A  Obtain a prescription for an oral formulation without altering the dose.
Explain to the patient that the drug becomes inactive if it is taken orally.

B  Explain to the patient that the drug causes toxic effects if it is taken orally.
Obtain a prescription for an oral formulation without altering the dose.

C  Obtain a prescription for an enteric-coated oral formulation to prevent inactivation in the liver.
Obtain a prescription for an oral formulation without altering the dose.

D  Explain to the patient that the drug becomes inactive if it is taken orally.
Explain to the patient that the drug will have a reduced effect if it is taken orally.

A  It will become zero.

B  It will be increased.

C  It will be decreased.

D  It will be unaffected.

A  Intranasal, Intraocular, and Transdermal

B  Injection into the portal vein and Transdermal

C  Injection into the portal vein and Oral

D  Intranasal, Injection into the portal vein and Oral

A  Initiate therapy with a lower-than-recommended dose.

B  Increase the dose from the recommended dose.

C  Prescribe an antibiotic with a low therapeutic index.

D  Administer the antibiotic with diuretic medications.

A  Grapefruit

B  Spinach

C  Yogurt

D  Cheese

A  Enteric-coated tablet

B  Capsule

C  Oral suspension

D  Elixir

A  Administering the medication via the Z-track method

B  Massaging the site after injection

C  Lowering the extremity below the level of the heart

D  Applying cold packs to the injection site

A  The therapeutic index of the drug may have been high.

B  The patient may have taken an excess dose of the drug.

C  The patient may have taken the drug with grapefruit juice.

D  The patient may have a deficiency of drug-metabolizing enzymes.

A  Acetaminophen

B  Amoxicillin

C  Ibuprofen

D  Warfarin

A  Palliative

B  Empiric

C  Prophylactic

D  Maintenance

A  Dissolve the granules in a beverage.

B  Chew the granules in the capsule.

C  Open the capsule and sprinkle the granules on soft food.

D  Crush the capsule.

A  “I should avoid giving the patient milk.”

B  “I should avoid giving the patient green leafy vegetables.”

C  “I should avoid giving the patient orange juice.”

D  “I should avoid giving the patient aged cheese.”

A  “Take the drug with iron-rich foods like spinach.”

B  “Take the drug with vitamin supplements.”

C  “Avoid taking the drug with milk.”

D  “Take an antacid with the drug.”

A  There is a high possibility that overdose events will occur.

B  The chances of side effects are low with this drug relative to other drugs.

C  The drug will have low tolerance when compared with other drugs.

D  There is less possibility of developing dependence.

A  A large percentage of an intravenously administered drug is metabolized into inactive metabolites in the liver.

B  Medications given orally bypass the portal circulatory system.

C  Drugs administered intravenously enter the portal system before systemic distribution.

D  Medications given intravenously are not affected by the first-pass effect.

A  The drug should be taken with large amounts of food. The drug should be crushed before administration.

B  Anticholinergic drugs may negate the effect of the enteric coating. Dissolution of the drug in the stomach is prevented.

C  Absorption of the drug in the intestine is prevented.The drug should be taken with large amounts of food.

D  The drug should be crushed before administration. Absorption of the drug in the intestine is prevented.

A  Hemolysis of platelets

B  Hemolysis of white blood cells

C  Hemolysis of red blood cells

D  Bone marrow suppression

A  It negates the action of the drug.

B  It reduces the metabolism of the drug.

C  It increases excretion of the drug.

D  It chemically binds to the drug.

A  60 mg/L

B  50 mg/L

C  20 mg/L

D  10 mg/L

A  50 mg/L

B  40 mg/L

C  25 mg/L

D  75 mg/L

A  Intramuscularly

B  Intravenously

C  Intrathecally

D  Subcutaneously

A  Pharmaceutics

B  Pharmacokinetics

C  Pharmacodynamics

D  Pharmacotherapeutics

A  Receptor interaction

B  Selective interaction

C  Enzyme interaction

D  Nonselective interaction

A  Elixir

B  Oral soluble wafer

C  Powder

D  Suspension

A  Formation of active metabolites is high in bile.

B  Formation of inactive metabolites is high in feces.

C  Formation of inactive metabolites is low in the kidneys.

D  Formation of inactive metabolites is high in the liver.

A  Mucosal cells

B  White blood cells

C  Platelets

D  Red blood cells

A  Drug interaction

B  Pharmacologic

C  Allergic

D  Idiosyncratic

A  Palliative

B  Supplemental

C  Prophylactic

D  Maintenance

A  Altering metabolic chemical processes. Making the cell perform a new function

B  Interacting with receptors. Altering metabolic chemical processes. Inhibiting the action of a specific enzyme

C  Altering metabolic chemical processes. Inhibiting the action of a specific enzyme. Making the cell perform a new function

D  None of these

A  Subcutaneous

B  Rectal

C  Sublingual

D  Oral

A  Resection of the small intestine

B  Seizure disorder

C  Left lower leg amputation

D  Coronary artery bypass graft

A  Additive

B  Adverse

C  Synergistic

D  Antagonistic

A  Administration with 8 ounces of water is required.

B  The risk of drug–drug interactions is increased.

C  The duration of action is typically short.

D  The effect is decreased in patients with a low albumin level.

A  Ptyalin

B  P450 enzymes

C  Gastric lipase

D  Pancreatic lipase

A  Contraindication

B  Idiosyncratic reaction

C  Drug interaction

D  Allergy

A  Palliative

B  Supplemental

C  Maintenance

D  Acute

A  Physiologic interactions of drugs

B  Distribution rates among various body compartments

C  Adverse reactions to medications

D  Interactions among various drugs

A  Acute

B  Supportive

C  Maintenance

D  Supplemental

A  Antagonistic

B  Synergistic

C  Incompatibility

D  Additive

A  Be eliminated by the body

B  Reach a therapeutic level

C  Be absorbed by the body

D  Exert a response

A  Oral

B  Intravenous

C  Sublingual

D  Subcutaneous

A  70%

B  50%

C  60%

D  100%

A  Mouse

B  Rabbit

C  Horse

D  Pig

A  Tolerance

B  Therapeutic index

C  Dependence

D  Addiction

A  Absorption

B  Metabolism

C  Excretion

D  Dilution

A  Dermatologic

B  Immune

C  Circulatory

D  Nervous

A  Oral

B  Transdermal

C  Rectal

D  Topical