Mastery EAQ Ch. 2

A  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin. Probenecid prevents the renal excretion of amoxicillin.

B  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

C  Combination therapy is beneficial to the patient. Probenecid prevents the renal excretion of amoxicillin. Probenecid increases the duration of action of amoxicillin.

D  Probenecid reduces allergic reactions to amoxicillin. Probenecid increases the duration of action of amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

A  Supplemental

B  Maintenance

C  Empiric

D  Prophylactic

A  Decreased pharmacologic effects of drugs

B  Delay in drug absorption

C  Shortened duration of drug actions

D  Development of drug toxicity

A  Hypotension

B  Urticaria

C  Rash

D  Anaphylactic shock

A  Explain to the patient that the drug becomes inactive if it is taken orally.
Explain to the patient that the drug will have a reduced effect if it is taken orally.

B  Explain to the patient that the drug causes toxic effects if it is taken orally.
Obtain a prescription for an oral formulation without altering the dose.

C  Obtain a prescription for an oral formulation without altering the dose.
Explain to the patient that the drug becomes inactive if it is taken orally.

D  Obtain a prescription for an enteric-coated oral formulation to prevent inactivation in the liver.
Obtain a prescription for an oral formulation without altering the dose.

A  It will be decreased.

B  It will be unaffected.

C  It will become zero.

D  It will be increased.

A  Intranasal, Injection into the portal vein and Oral

B  Injection into the portal vein and Oral

C  Intranasal, Intraocular, and Transdermal

D  Injection into the portal vein and Transdermal

A  Increase the dose from the recommended dose.

B  Initiate therapy with a lower-than-recommended dose.

C  Administer the antibiotic with diuretic medications.

D  Prescribe an antibiotic with a low therapeutic index.

A  Spinach

B  Yogurt

C  Cheese

D  Grapefruit

A  Elixir

B  Enteric-coated tablet

C  Oral suspension

D  Capsule

A  Administering the medication via the Z-track method

B  Lowering the extremity below the level of the heart

C  Applying cold packs to the injection site

D  Massaging the site after injection

A  The patient may have a deficiency of drug-metabolizing enzymes.

B  The patient may have taken the drug with grapefruit juice.

C  The patient may have taken an excess dose of the drug.

D  The therapeutic index of the drug may have been high.

A  Acetaminophen

B  Warfarin

C  Ibuprofen

D  Amoxicillin

A  Empiric

B  Prophylactic

C  Palliative

D  Maintenance

A  Crush the capsule.

B  Open the capsule and sprinkle the granules on soft food.

C  Chew the granules in the capsule.

D  Dissolve the granules in a beverage.

A  “I should avoid giving the patient aged cheese.”

B  “I should avoid giving the patient milk.”

C  “I should avoid giving the patient orange juice.”

D  “I should avoid giving the patient green leafy vegetables.”

A  “Take an antacid with the drug.”

B  “Take the drug with iron-rich foods like spinach.”

C  “Avoid taking the drug with milk.”

D  “Take the drug with vitamin supplements.”

A  The chances of side effects are low with this drug relative to other drugs.

B  The drug will have low tolerance when compared with other drugs.

C  There is a high possibility that overdose events will occur.

D  There is less possibility of developing dependence.

A  A large percentage of an intravenously administered drug is metabolized into inactive metabolites in the liver.

B  Medications given intravenously are not affected by the first-pass effect.

C  Medications given orally bypass the portal circulatory system.

D  Drugs administered intravenously enter the portal system before systemic distribution.

A  The drug should be taken with large amounts of food. The drug should be crushed before administration.

B  Absorption of the drug in the intestine is prevented.The drug should be taken with large amounts of food.

C  Anticholinergic drugs may negate the effect of the enteric coating. Dissolution of the drug in the stomach is prevented.

D  The drug should be crushed before administration. Absorption of the drug in the intestine is prevented.

A  Hemolysis of platelets

B  Hemolysis of white blood cells

C  Bone marrow suppression

D  Hemolysis of red blood cells

A  It chemically binds to the drug.

B  It increases excretion of the drug.

C  It negates the action of the drug.

D  It reduces the metabolism of the drug.

A  10 mg/L

B  50 mg/L

C  60 mg/L

D  20 mg/L

A  75 mg/L

B  25 mg/L

C  50 mg/L

D  40 mg/L

A  Subcutaneously

B  Intravenously

C  Intramuscularly

D  Intrathecally

A  Pharmacotherapeutics

B  Pharmaceutics

C  Pharmacokinetics

D  Pharmacodynamics

A  Selective interaction

B  Enzyme interaction

C  Nonselective interaction

D  Receptor interaction

A  Oral soluble wafer

B  Suspension

C  Elixir

D  Powder

A  Formation of active metabolites is high in bile.

B  Formation of inactive metabolites is low in the kidneys.

C  Formation of inactive metabolites is high in feces.

D  Formation of inactive metabolites is high in the liver.

A  Red blood cells

B  Mucosal cells

C  Platelets

D  White blood cells

A  Pharmacologic

B  Drug interaction

C  Allergic

D  Idiosyncratic

A  Palliative

B  Supplemental

C  Prophylactic

D  Maintenance

A  None of these

B  Altering metabolic chemical processes. Making the cell perform a new function

C  Altering metabolic chemical processes. Inhibiting the action of a specific enzyme. Making the cell perform a new function

D  Interacting with receptors. Altering metabolic chemical processes. Inhibiting the action of a specific enzyme

A  Oral

B  Rectal

C  Subcutaneous

D  Sublingual

A  Seizure disorder

B  Left lower leg amputation

C  Resection of the small intestine

D  Coronary artery bypass graft

A  Antagonistic

B  Synergistic

C  Adverse

D  Additive

A  The risk of drug–drug interactions is increased.

B  The effect is decreased in patients with a low albumin level.

C  Administration with 8 ounces of water is required.

D  The duration of action is typically short.

A  P450 enzymes

B  Ptyalin

C  Gastric lipase

D  Pancreatic lipase

A  Contraindication

B  Allergy

C  Idiosyncratic reaction

D  Drug interaction

A  Palliative

B  Acute

C  Maintenance

D  Supplemental

A  Adverse reactions to medications

B  Interactions among various drugs

C  Distribution rates among various body compartments

D  Physiologic interactions of drugs

A  Supplemental

B  Maintenance

C  Acute

D  Supportive

A  Antagonistic

B  Additive

C  Incompatibility

D  Synergistic

A  Exert a response

B  Reach a therapeutic level

C  Be eliminated by the body

D  Be absorbed by the body

A  Oral

B  Subcutaneous

C  Intravenous

D  Sublingual

A  60%

B  70%

C  50%

D  100%

A  Rabbit

B  Horse

C  Mouse

D  Pig

A  Therapeutic index

B  Dependence

C  Tolerance

D  Addiction

A  Excretion

B  Metabolism

C  Absorption

D  Dilution

A  Nervous

B  Circulatory

C  Immune

D  Dermatologic

A  Rectal

B  Topical

C  Oral

D  Transdermal