Mastery EAQ Ch. 2

A  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin. Probenecid prevents the renal excretion of amoxicillin.

B  Probenecid reduces allergic reactions to amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

C  Probenecid reduces allergic reactions to amoxicillin. Probenecid increases the duration of action of amoxicillin. Probenecid enhances the antibacterial action of amoxicillin.

D  Combination therapy is beneficial to the patient. Probenecid prevents the renal excretion of amoxicillin. Probenecid increases the duration of action of amoxicillin.

A  Prophylactic

B  Empiric

C  Maintenance

D  Supplemental

A  Development of drug toxicity

B  Delay in drug absorption

C  Shortened duration of drug actions

D  Decreased pharmacologic effects of drugs

A  Rash

B  Hypotension

C  Urticaria

D  Anaphylactic shock

A  Explain to the patient that the drug causes toxic effects if it is taken orally.
Obtain a prescription for an oral formulation without altering the dose.

B  Obtain a prescription for an oral formulation without altering the dose.
Explain to the patient that the drug becomes inactive if it is taken orally.

C  Explain to the patient that the drug becomes inactive if it is taken orally.
Explain to the patient that the drug will have a reduced effect if it is taken orally.

D  Obtain a prescription for an enteric-coated oral formulation to prevent inactivation in the liver.
Obtain a prescription for an oral formulation without altering the dose.

A  It will be unaffected.

B  It will be decreased.

C  It will become zero.

D  It will be increased.

A  Intranasal, Injection into the portal vein and Oral

B  Injection into the portal vein and Oral

C  Injection into the portal vein and Transdermal

D  Intranasal, Intraocular, and Transdermal

A  Initiate therapy with a lower-than-recommended dose.

B  Prescribe an antibiotic with a low therapeutic index.

C  Increase the dose from the recommended dose.

D  Administer the antibiotic with diuretic medications.

A  Spinach

B  Cheese

C  Grapefruit

D  Yogurt

A  Elixir

B  Enteric-coated tablet

C  Capsule

D  Oral suspension

A  Lowering the extremity below the level of the heart

B  Administering the medication via the Z-track method

C  Massaging the site after injection

D  Applying cold packs to the injection site

A  The patient may have taken an excess dose of the drug.

B  The patient may have a deficiency of drug-metabolizing enzymes.

C  The patient may have taken the drug with grapefruit juice.

D  The therapeutic index of the drug may have been high.

A  Amoxicillin

B  Ibuprofen

C  Acetaminophen

D  Warfarin

A  Prophylactic

B  Maintenance

C  Empiric

D  Palliative

A  Open the capsule and sprinkle the granules on soft food.

B  Chew the granules in the capsule.

C  Dissolve the granules in a beverage.

D  Crush the capsule.

A  “I should avoid giving the patient orange juice.”

B  “I should avoid giving the patient aged cheese.”

C  “I should avoid giving the patient green leafy vegetables.”

D  “I should avoid giving the patient milk.”

A  “Take the drug with iron-rich foods like spinach.”

B  “Take the drug with vitamin supplements.”

C  “Take an antacid with the drug.”

D  “Avoid taking the drug with milk.”

A  There is a high possibility that overdose events will occur.

B  The drug will have low tolerance when compared with other drugs.

C  There is less possibility of developing dependence.

D  The chances of side effects are low with this drug relative to other drugs.

A  Medications given orally bypass the portal circulatory system.

B  Medications given intravenously are not affected by the first-pass effect.

C  Drugs administered intravenously enter the portal system before systemic distribution.

D  A large percentage of an intravenously administered drug is metabolized into inactive metabolites in the liver.

A  Absorption of the drug in the intestine is prevented.The drug should be taken with large amounts of food.

B  The drug should be crushed before administration. Absorption of the drug in the intestine is prevented.

C  The drug should be taken with large amounts of food. The drug should be crushed before administration.

D  Anticholinergic drugs may negate the effect of the enteric coating. Dissolution of the drug in the stomach is prevented.

A  Hemolysis of platelets

B  Hemolysis of white blood cells

C  Bone marrow suppression

D  Hemolysis of red blood cells

A  It negates the action of the drug.

B  It increases excretion of the drug.

C  It chemically binds to the drug.

D  It reduces the metabolism of the drug.

A  10 mg/L

B  20 mg/L

C  60 mg/L

D  50 mg/L

A  40 mg/L

B  75 mg/L

C  25 mg/L

D  50 mg/L

A  Subcutaneously

B  Intramuscularly

C  Intrathecally

D  Intravenously

A  Pharmacokinetics

B  Pharmaceutics

C  Pharmacodynamics

D  Pharmacotherapeutics

A  Enzyme interaction

B  Selective interaction

C  Nonselective interaction

D  Receptor interaction

A  Elixir

B  Powder

C  Suspension

D  Oral soluble wafer

A  Formation of inactive metabolites is high in the liver.

B  Formation of inactive metabolites is high in feces.

C  Formation of inactive metabolites is low in the kidneys.

D  Formation of active metabolites is high in bile.

A  White blood cells

B  Mucosal cells

C  Red blood cells

D  Platelets

A  Drug interaction

B  Idiosyncratic

C  Allergic

D  Pharmacologic

A  Prophylactic

B  Supplemental

C  Maintenance

D  Palliative

A  Altering metabolic chemical processes. Inhibiting the action of a specific enzyme. Making the cell perform a new function

B  Altering metabolic chemical processes. Making the cell perform a new function

C  Interacting with receptors. Altering metabolic chemical processes. Inhibiting the action of a specific enzyme

D  None of these

A  Subcutaneous

B  Rectal

C  Sublingual

D  Oral

A  Resection of the small intestine

B  Seizure disorder

C  Left lower leg amputation

D  Coronary artery bypass graft

A  Antagonistic

B  Additive

C  Synergistic

D  Adverse

A  The duration of action is typically short.

B  The risk of drug–drug interactions is increased.

C  The effect is decreased in patients with a low albumin level.

D  Administration with 8 ounces of water is required.

A  Gastric lipase

B  P450 enzymes

C  Ptyalin

D  Pancreatic lipase

A  Drug interaction

B  Contraindication

C  Idiosyncratic reaction

D  Allergy

A  Maintenance

B  Acute

C  Supplemental

D  Palliative

A  Adverse reactions to medications

B  Physiologic interactions of drugs

C  Interactions among various drugs

D  Distribution rates among various body compartments

A  Acute

B  Supplemental

C  Maintenance

D  Supportive

A  Incompatibility

B  Additive

C  Synergistic

D  Antagonistic

A  Be eliminated by the body

B  Be absorbed by the body

C  Exert a response

D  Reach a therapeutic level

A  Subcutaneous

B  Oral

C  Intravenous

D  Sublingual

A  60%

B  50%

C  70%

D  100%

A  Mouse

B  Pig

C  Rabbit

D  Horse

A  Dependence

B  Therapeutic index

C  Addiction

D  Tolerance

A  Absorption

B  Excretion

C  Dilution

D  Metabolism

A  Dermatologic

B  Nervous

C  Immune

D  Circulatory

A  Topical

B  Transdermal

C  Rectal

D  Oral