Exam 2 (B)

A  It activates an autoimmune disease that destroys myelin.

B  It will cause persistent twitches with short periods of rest in between.

C  Muscle function is fine, but it will cause a loss of voluntary control.

D  It will cause spastic paralysis (sustained, unwanted muscle contraction).

E  It will cause flaccid paralysis (no muscle contraction possible).

A  They depolarize postsynaptic cell membranes.

B  They are always the same amplitude.

C  They transmit signals over relatively short distances.

D  They are produced by the opening of ligand-gated sodium channels.

E  They are able to summate.

A  They cause the absolute refractory period to be very brief.

B  They are directly responsible for making cardiac muscle fatigue-resistant.

C  They act as non-conducting voltage sensors that mediate excitation-contraction coupling.

D  They are responsible for preventing tetanic contractions.

E  They function exactly the same in cardiac muscle cells as they do in skeletal muscle.

A  In skeletal muscle, calcium initiates contraction by binding to troponin, while in smooth muscle calcium initiates contraction by binding directly to myosin.

B  In skeletal muscle, calcium initiates contraction by binding to myosin light-chain kinase, while in smooth muscle calcium initiates contraction by binding directly to tropomyosin.

C  All of the choices are true.

D  In skeletal muscle, calcium initiates contraction by binding to troponin, while in smooth muscle calcium initiates contraction by binding to calmodulin.

E  In skeletal muscle, calcium ions bind to a regulatory protein on thin filaments; in smooth muscle, calcium ions bind to a regulatory protein on thick filaments.

A  The shorter a skeletal muscle cell is when it begins to contract, the stronger the force generation will be.

B  Skeletal muscle cells generate the same amount of force, regardless of their length.

C  Skeletal muscle cells generate the most force when the contraction occurs at an intermediate length.

D  The tension in a skeletal muscle cell is greatest when contractions occur at either very short or very long lengths.

E  The longer a skeletal muscle cell is when it begins to contract, the stronger the force generation will be.

A  bound to muscarinic receptors at the end plate.

B  bound to Ca2+ ions.

C  bound to receptors on the sarcoplasmic reticulum.

D  inside the muscle cell sarcoplasm.

E  bound to acetylcholinesterase in the end plate membrane.

A  A very large amplitude action potential in the motor neuron causes a very strong contraction in the skeletal muscle cell.

B  The action potential in the muscle cell is prolonged to last as long as the contraction.

C  Multiple action potentials in the motor neuron cause a sustained contraction.

D  Repeated action potentials from the motor neuron summate into a sustained depolarization of the motor end plate, causing a sustained contraction.

E  A single action potential in the motor neuron causes a sustained contraction.

A  By the duration of action potentials

B  By whether the action potential peak is positive or negative

C  By the size of action potentials

D  By the frequency of action potentials

A  ATP; detachment

B  calcium; detachment

C  calcium; attachment

D  actin; detachment

E  ATP; attachment

A  the whole muscle shortens.

B  tension generated by the muscle always exceeds the load on the muscle.

C  H zones shorten.

D  tetanus occurs.

E  sarcomeres do not significantly shorten.

A  leg muscles with a larger diameter.

B  a higher density of capillaries in her leg muscles.

C  lower concentrations of glycolytic enzymes in her leg muscles.

D  leg muscles with a smaller diameter.

E  hypertrophy of type I muscle fibers.

A  The order of recruitment of motor units in a muscle is such that the first units recruited generate the most tension.

B  Motor units whose motor neurons have large-diameter cell bodies are recruited first, while motor units with smaller-diameter motor neurons are only activated as the level of activation in the spinal cord increases.

C  The order of recruitment of motor units in a muscle is such that the last units recruited are those that fatigue most readily.

D  Recruitment of one fast-glycolytic motor unit provides a smaller increment in whole-muscle tension than recruitment of one slow-oxidative motor unit.

E  The order of motor unit recruitment is independent of the size of the alpha motor neuron that innervates them.

A  None of the answer choices are correct

B  Muscle cell twitches (contractions)

C  Muscle paralysis

D  Muscle relaxation

E  Drowsiness

A  They are both excitatory.

B  Z is excitatory and Y is inhibitory.

C  Y is excitatory and Z is inhibitory.

D  They are both inhibitory.

A  Na+ permeability that is greater than that during the depolarization phase.

B  increased K+ flux into the cell.

C  Increased Na+ flux through K+ channels.

D  increased K+ permeability of the cell.

E  activation and inactivation of voltage-dependent Na+ channels.

A  PK+ becomes much greater than PNa+.

B  Na+ efflux (flow out of the cell) occurs.

C  K+ flows rapidly into the cell.

D  PK+ is the same as PNa+.

E  PNa+ becomes much greater than PK+.

A  proteins associated with synaptic vesicles.

B  lysosomal proteins.

C  kinesin proteins.

D  smooth endoplasmic reticulum.

E  dyenin proteins.

A  Ca2+ is released from the sarcoplasmic reticulum.

B  Cross-bridges rotate, sliding past the thin filament.

C  Actin binds to myosin.

D  Actin dissociates from myosin.

E  Cross-bridge heads are cocked into an “energized” state.

A  The repolarization phase of the action potential

B  The exocytosis of neurotransmitter

C  All of these will not occur

D  The depolarization phase of the action potential

E  The graded potential

A  A drug that inhibits acetylcholinesterase

B  Curare

C  Atropine (a muscarinic acetylcholine receptor antagonist)

D  A nicotinic acetylcholine receptor antagonist

E  A drug that inhibits release of acetylcholine

A  Calcium release into cytosol, actin and myosin attach, calcium ion influx through sarcolemma, thin myofilaments slide toward the middle of sarcomeres

B  Calcium ion influx through sarcolemma, calcium release into cytosol, actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres

C  Calcium release into cytosol, calcium ion influx through sarcolemma, actin and myosin attach, thin filaments slide toward the middle of sarcomeres

D  Calcium release into cytosol, actin and myosin attach, thin filaments slide toward the middle of sarcomeres, calcium ion influx through sarcolemma

E  Actin and myosin attach, thin filaments slide toward the middle of sarcomeres, calcium release into cytosol

A  The concentration of sodium ion is greater inside the cell than outside.

B  The plasma membrane is completely impermeable to potassium ions.

C  The plasma membrane is most permeable to sodium ions.

D  The permeability of the plasma membrane to potassium ions is much greater than its permeability to sodium ions.

E  The plasma membrane is completely impermeable to sodium ions.

A  Endorphin

B  Gamma-aminobutyric acid (GABA)

C  Norepinephrine

D  Dopamine

E  Glutamate

A  Smooth muscle does not have thick and thin filaments.

B  The myosin in smooth muscle requires phosphorylation before it can bind to ATP.

C  Changes in cytosolic calcium do not regulate cross-bridge activity in smooth muscle.

D  Smooth muscle does not use troponin-tropomyosin to regulate cross-bridge activity.

E  Smooth muscle is striated.

A  All muscles of the body might exhibit frequent small twitches.

B  All muscles of the body will be completely normal in function.

C  All muscles of the body might present a limp, relaxed state known as flaccid paralysis.

D  All muscles of the body might present a tense, fully contracted state.

A  Every moment of Sarah’s runs

B  Just the first few seconds of exercise

C  All muscle contractions after Sarah reaches her maximum heart rate (about 10 minutes into her run)

D  All muscle contractions after Sarah reaches fatigue (about an hour into her run)

E  No effects on her running

A  All of the K+ channels in the membrane are open.

B  Most of the voltage-gated Na+ channels are in the closed state.

C  The voltage-gated Na+ channels are in the inactivated state.

D  There is equal permeability to Na+ and K+.

E  The permeability to Na+ is much greater than the permeability to K+.

A  They form the Z lines that mark the end of each sarcomere.

B  They manufacture and store ATP.

C  They run in parallel with the myofibrils, and have abundant Ca2+-ATPase proteins for pumping Ca2+ back into the sarcoplasmic reticulum.

D  They store the calcium ions that are the main source of activation for the cross-bridge cycle.

E  They allow action potentials to propagate deep into the center of skeletal muscle cells.

A  Troponin covers the binding site on myosin molecules until Ca2+ binds to troponin to remove it from its blocking position.

B  All of the myosin cross-bridge heads in a thick filament are oriented and rotate in the same direction.

C  Myosin cross-bridge heads contain two binding sites, one for actin and one for tropomyosin.

D  Myosin is an ATPase.

E  The rate of ATP hydrolysis by myosin is the same in all types of skeletal muscle.

A  It only refers to addition of EPSPs.

B  A synapse is stimulated a second time before the effect of a first stimulus at the synapse has terminated.

C  It always brings a postsynaptic cell to threshold.

D  Two synapses on different regions of a cell are stimulated at the same time.

E  The size of an EPSP depends on the size of the stimulus.

A  Skeletal muscle usually exhibits spontaneous activity, while smooth muscle cannot contract spontaneously. 

B  Only skeletal muscle requires increased calcium ion concentration in the cytosol for contraction.

C  Only skeletal muscle has both actin and myosin.

D  Myosin is the main regulatory protein in smooth muscle.

E  Myosin is the main regulatory protein in skeletal muscle.

A  In skeletal muscle cells, it requires the influx of extracellular calcium ion.

B  In skeletal muscle cells, excitation-contraction coupling begins when an action potential propagates along the sarcoplasmic reticulum membrane.

C  In smooth muscle cells, it must be preceded by an action potential in the cell membrane.

D  In all kinds of muscle it requires the entry of calcium from the extracellular fluid.

E  Calcium-induced calcium release plays a role in cardiac muscle cells, as well as in some smooth muscle cells.

A  The refractory period places an upper limit on the frequency with which a nerve cell can conduct action potentials.

B  The relative refractory period refers to the period of time during which another action potential can be initiated in that part of the membrane that has just undergone an action potential if a stronger than normal stimulus is applied

C  The absolute refractory period refers to the period of time during which another action potential cannot be initiated in that part of the membrane that is undergoing an action potential, no matter how great the strength of the stimulus.
The refractory period prevents the action potential from spreading back over the part of the membrane that just underwent an action potential.

D  The refractory period prevents the action potential from spreading back over the part of the membrane that just underwent an action potential.
The relative refractory period refers to the period of time during which another action potential can be initiated in that part of the membrane that has just undergone an action potential if a stronger than normal stimulus is applied.
The refractory period places an upper limit on the frequency with which a nerve cell can conduct action potentials.
The absolute refractory period refers to the period of time during which another action potential cannot be initiated in that part of the membrane that is undergoing an action potential, no matter how great the strength of the stimulus.

A  Contraction will occur, but the muscle will be stuck in the contracted state and unable to relax.

B  Binding of myosin to actin will take place.

C  Tropomyosin will continue to cover the myosin binding sites on actin and no cross-bridges will form.

D  Only one cross-bridge cycle will occur but no second cycle. 

E  A single twitch in skeletal muscle but no sustained contraction.

A  The permeability to Na+ increases greatly.

B  ATPase destroys the energy supply that was maintaining the action potential at its peak.

C  The permeability to K+ increases greatly while that to Na+ decreases.

D  Voltage-gated Na+ channels are opened.

E  The Na+, K+ pump restores the ions to their original locations inside and outside of the cell.

A  actin.

B  myosin.

C  tropomyosin.

D  troponin.

E  the thick filament.

A  Type 2X fibers have more abundant mitochondria.

B  Type 2X fibers fatigue more readily.

C  Type 2X fibers are smaller in diameter.

D  Type 2X motor units contain fewer fibers per alpha motor neuron

E  Type 2X fibers have more abundant myoglobin.

A  trigger an action potential.

B  depolarize a dendrite.

C  trigger an excitatory postsynaptic potential.

D  cause a change in membrane potential.

E  be conducted to the axon hillock.

A  In the absence of any neural input, skeletal muscle cannot generate tension.

B  Synaptic input onto skeletal muscle cells is always excitatory, whereas inputs to smooth muscle cells may be either excitatory or inhibitory.

C  A single smooth muscle cell may be innervated by both a sympathetic neuron and a parasympathetic neuron.

D  Contractile activity of smooth muscle cells does not normally require Ca2+.

E  Ca2+ that activates contraction of smooth muscles can come from either the ECF or from the sarcoplasmic reticulum.

A  A single muscle fiber plus all of the motor neurons that innervate it

B  All of the muscles that affect the movement of any given joint

C  A pair of antagonistic muscles

D  All of the motor neurons supplying a single muscle

E  A single motor neuron plus all the muscle fibers it innervates

A  Dopamine

B  Beta-endorphin

C  Gamma-aminobutyric acid (GABA)

D  Norepinephrine

E  Glutamate

A  There will be no change to the membrane potential in the postsynaptic cell.

B  The postsynaptic cell will immediately undergo an action potential.

C  The postsynaptic cell will undergo an IPSP.

D  The postsynaptic cell will undergo an EPSP.

A  an action potential is propagated without decrement, whereas a graded potential decrements with distance.

B  movement of Na+ and K+ across cell membranes mediate action potentials, while graded potentials do not involve movement of Na+ and K+.

C  an action potential has a threshold, whereas a graded potential is an all-or-none phenomenon.

D  action potentials vary in size with the size of a stimulus, while graded potentials do not.

E  an action potential requires the opening of Ca2+ channels, whereas a graded potential does not.

A  agonist to glycine receptors.

B  Any of these are possible

C  agonist to the endogenous opioid receptors.

D  agonist to epinephrine receptors.

E  agonist to serotonin receptors.